Continuous Pharmaceutical Powder Mixing Process Modeling

Continuous manufacturing (CM) of oral drug products can deliver high quality oral solid dose products, with greater flexibility and at a reduced cost of supply. Designing such continuous operations requires the evaluation of a large parametric space.

Featuring Peyman Aminpour, R&D Scientist at Thermo Fischer Scientific, this webinar explains how the Discrete Element Method (DEM) was used to develop a digital twin for a commercial continuous blender in order to evaluate the effects of critical process parameters (CPPs) including impeller rotation rate, feed flow rate, and relationship with material properties on the blender performance.