The presentation outlines a solution strategy for how a digital twin of a milling machine is solving mechatronic challenges. To improve cycle times, accuracy, and addressing vibration problems a holistic system simulation serves as the basis for optimization. The efficient modeling of the real system behavior with flexibilities, contacts, gaps, friction, nonlinearities in the drives (incl. saturation effects of motors), power electronics in combination with the control system is the basis for efficient controller design and optimization of the control parameters. The dynamic interaction of multiple system components combining 3D finite elements analysis multi-body dynamics and control system helps avoiding Tracking-, drag-, positioning errors rebound, and accumulation effects.