With the increasingly stringent environment and energy sustainability, electric vehicles now become a game-changing choice for the automotive industry. By adopting recently developed high energy density, current electric vehicles have solved the “range anxiety” to a great extent. However, increased safety risk with high energy density cells as well as the cell number, pose two strongly coupled headaches to the researchers and engineers, namely, safety issues of the battery and the heavyweight of the electric vehicles. In this talk, from the lithium-ion battery perspective, I will introduce the state-of-the-art research progress and new problem-solving concepts towards these naturally multiphysics-related topics. Strategies, methodologies, and models introduced here can benefit all lithium-ion-battery-powered transportation tools, communication devices, and energy storage systems in a larger context.